Wow, some very thorough data to back this one up! Was a great read.<p>In addition to 'taking breaks' as you sumrize, I think it is helpful if we engineer our 'work' to be more flexible. Sure, if you build a business that is basically a deck-of-cards that could fall at any moment without your presence - those weekend get-togethers with friends and family are going to stress you out. On the other hand, if you build a business that can easily run on auto-pilot when you're not around - things will be a lot more care-free during breaks and life stuff.<p>Its something important to keep in mind when building a startup, but almost certainly an afterthought for most.