TE
科技回声
首页24小时热榜最新最佳问答展示工作
GitHubTwitter
首页

科技回声

基于 Next.js 构建的科技新闻平台,提供全球科技新闻和讨论内容。

GitHubTwitter

首页

首页最新最佳问答展示工作

资源链接

HackerNews API原版 HackerNewsNext.js

© 2025 科技回声. 版权所有。

Wegovy and Ozempic (semaglutide) associated with reduction in alcohol addiction

76 点作者 henryaj11 个月前

20 条评论

spacephysics11 个月前
We’re nearing the utopic phase for this drug (if we aren’t already there)<p>Mindful that this also lowers muscle mass (can weight train and eat enough protein to compensate slightly)<p>AND less easily mitigated lowers bone mass, weakens tendons, and weakens ligaments.<p>It’s a great option if the patient is diabetic and their current lifestyle&#x2F;condition has worse outcomes than the side effects listed, but we’re hearing from celebrities like this is a vitamin D pill
评论 #40565416 未加载
评论 #40565949 未加载
评论 #40565372 未加载
评论 #40565385 未加载
评论 #40565961 未加载
评论 #40565339 未加载
评论 #40570705 未加载
评论 #40565348 未加载
yuy91061611 个月前
Tangentially, I wonder how people mentally model &quot;too-good-to-be-true&quot;?<p>&quot;Everything is a tradeoff&quot; is almost a core belief for me, but in the same time, in technology, the &quot;too-good-to-be-true&quot; events does turn out to be real every once a while (I&#x27;m using technology here as a general concept).<p>I do understand GLP-1 does have some downsides, like cost, or in my own experience, nausea. But the tradeoff seems negligible compare to the upside. Part of me feels like that there is some hidden trade-off somewhere that we&#x27;re not discovering, but part of me also wonders if it&#x27;s a once in while technology jump, where it is just better.<p>Anyway, I guess I&#x27;m just a bit wary to throw away the &quot;everything is a tradeoff&quot; mental model that has worked quite well for me.
评论 #40565507 未加载
评论 #40571003 未加载
评论 #40572138 未加载
fiftyfifty11 个月前
The biggest problem with semaglutide is once you stop taking it things like blood sugar and body weight start to go back to where they were before. On average people gain back 70% of the weight they lost on the drug within the first year when they stop taking it. It seems likely this is going to be true with other addictions as well such as alcohol. While the effects are impressive, without addressing the underlying causes such as psychological factors that cause people to overeat or abuse other substances like alcohol it seems like we are just replacing one form of chemical dependance with another, albeit a healthier one.<p><a href="https:&#x2F;&#x2F;www.healthline.com&#x2F;health&#x2F;semaglutide-withdrawal-symptoms" rel="nofollow">https:&#x2F;&#x2F;www.healthline.com&#x2F;health&#x2F;semaglutide-withdrawal-sym...</a>
评论 #40565582 未加载
评论 #40565475 未加载
评论 #40565459 未加载
评论 #40565455 未加载
评论 #40565608 未加载
评论 #40565487 未加载
saberience11 个月前
I&#x27;m an interested bystander to this obesity drug mania currently happening but I&#x27;m curious as to whether the folks taking this for obesity or being overweight have to take it for the rest of their lives?<p>I.e. if an obese person gets skinny with Ozempic and then stops taking it, can they keep the weight off?<p>If not, it seems like the &quot;perfect&quot; money-making drug, i.e. it doesn&#x27;t cure anything permanently, its expensive, and patients have to take it until they die.<p>Now sure, it&#x27;s obviously better than being obese and unhealthy, but does it bother anyone else (in a philosophical kind of way), that we are treating the symptoms and not the causes here? We&#x27;re teaching people that everything can be solved by popping more pills and not treating the psychological issues that result in so much obesity. It also doesn&#x27;t result in anyone learning any good lesson, e.g. that working gets results. In this case the lesson is, my bad decisions or mental health don&#x27;t matter, I can just pop pills for all my problems...
评论 #40565483 未加载
评论 #40565464 未加载
评论 #40565845 未加载
评论 #40566215 未加载
toomuchtodo11 个月前
Very exciting, we&#x27;re going to see some serious &quot;at scale&quot; behavioral changes (obesity decline, addiction decline, possibly even social media usage decline) as soon as the cost of GLP-1 agonists gets driven down and manufacturing scales up.
评论 #40565331 未加载
评论 #40565346 未加载
评论 #40565306 未加载
hnburnsy11 个月前
A study says these drugs could prevent 1.5 million cardiac events over 10 years, add in a reduction in alcoholism and the governments should be giving away these drugs to save on healthcare costs...<p>----- We identified 3999 US adults weighted to an estimated population size of 93.0 million [M] (38% of US adults) who fit STEP 1 eligibility criteria. Applying STEP 1 treatment effects on weight loss resulted in an estimated 69.1% (64.3 M) and 50.5% (47.0 M) showing ≥ 10% and ≥ 15% weight reductions, respectively, translating to a 46.1% (43.0 M) reduction in obesity (BMI ≥ 30 kg&#x2F;m2) prevalence. Among those without CVD, estimated 10-year CVD risks were 10.15% “before” and 8.34% “after” semaglutide “treatment” reflecting a 1.81% absolute (and 17.8% relative) risk reduction translating to 1.50 million preventable CVD events over 10 years.<p><a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=37166206">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=37166206</a>
评论 #40566700 未加载
xxmarkuski11 个月前
The effects of GLP-1 drugs are fascinating and I am curious whether we will see approvals beyond the current diabetic and weight-loss applications. In just the last months stories of increased fertility [0] and reduction of heart attack risk [1] popped up, but more data is definitely needed to fully asses the effects.<p>[0] <a href="https:&#x2F;&#x2F;www.independent.co.uk&#x2F;life-style&#x2F;pregnant-women-ozempic-babies-b2517305.html" rel="nofollow">https:&#x2F;&#x2F;www.independent.co.uk&#x2F;life-style&#x2F;pregnant-women-ozem...</a><p>[1] <a href="https:&#x2F;&#x2F;www.theguardian.com&#x2F;science&#x2F;article&#x2F;2024&#x2F;may&#x2F;14&#x2F;weight-loss-drug-semaglutide-reduce-heart-attack-risk-study" rel="nofollow">https:&#x2F;&#x2F;www.theguardian.com&#x2F;science&#x2F;article&#x2F;2024&#x2F;may&#x2F;14&#x2F;weig...</a>
评论 #40565625 未加载
hackeraccount11 个月前
Anyone read David Brin&#x27;s story &quot;The Giving Plague.&quot;?<p>These drugs have the flavor of that. I&#x27;d be reluctant to take them not because the Thyroid cancer risk or loss of muscle mass. Or the possibility that if I stopped I might gain more weight then when I started.<p>I&#x27;d be reluctant because in it&#x27;s weird hormonal backdoor way it seems to be really messing with your personality. I&#x27;m not convinced the grass is actually greener on the other side - I tend to be of the belief that it&#x27;s no better or worse; it&#x27;s just a different set of tradeoffs.<p>All that said while I&#x27;m not skinny I&#x27;m also not (in my and I assume my dr&#x27;s judgement) a candidate for this drug. Maybe if I was I&#x27;d feel differently.
manacit11 个月前
It&#x27;s exciting to see when we&#x27;re so early in the journey of GLP-1 drugs.<p>The dual action tirzepatide and the next generation retatrutide that has shown massive ability to reduce the long-term harm from obesity: <a href="https:&#x2F;&#x2F;www.vcuhealth.org&#x2F;news&#x2F;retatrutide-wiped-out-fat-in-liver-of-obese-patients" rel="nofollow">https:&#x2F;&#x2F;www.vcuhealth.org&#x2F;news&#x2F;retatrutide-wiped-out-fat-in-...</a><p>I&#x27;m sure there will be many comments here discussing how awful the side effects are, but from what I can see they&#x27;re almost all primarily associated with rapid weight loss in general - muscle mass reduction and whatnot seem inevitable when someone drops 100+ lbs of total body weight.
mullingitover11 个月前
I&#x27;m curious how much damage GLP-1 agonists will do to the extremely profitable industries that depend on addiction before we&#x27;ll start hearing scare stories about extremely rare side effects, followed by politically expedient bans.
评论 #40566718 未加载
评论 #40565563 未加载
suzzer9911 个月前
I&#x27;ve been on Zepbound for 5 weeks now and it&#x27;s basically a miracle drug as far as I&#x27;m concerned. Food still tastes good, but the urge is gone. It&#x27;s like going from being a sex addict to someone with very low sex drive.<p>It&#x27;s not just the lack of hunger, but I don&#x27;t get hangry, which was an even bigger problem than resisting the food. I&#x27;d get legitimately obsessive about the stupidest little things, to where I&#x27;d jeopardize my job and every relationship in my life if I kept going that way.<p>I knew things were different when I ate two pieces of pizza and then the box sat there in front of me for hours w&#x2F;o me even thinking about it. Normally as soon as I knew everyone else had their fill, I would have finished the two pieces left in the box. If I tried to resist, the pizza would be calling me from inside the box every 5 seconds. It would be like a crack addict sitting there looking at a loaded crack pipe for 2 hours and not taking a hit.<p>Another moment was when I got the &quot;I&#x27;m full, I don&#x27;t want to finish this&quot; message from my stomach while eating a small cakepop. I&#x27;ve gotten that feeling before from eating too much meat, like at a Brazilian steakhouse, but <i>never</i> from anything sweet and carby. Just knowing this is how some people live has been a huge eye-opener for me. I totally get the whole ectomorph&#x2F;endomorph thing now.<p>So far I&#x27;ve lost 10 lbs. I make sure to get plenty of protein and have to force myself to eat sometimes. I try to eat more early in the week when I do my hardest workouts. I&#x27;m still lifting the same amount. I haven&#x27;t gone up, but I haven&#x27;t gone down, which is great.<p>I workout 4x a week and also walk&#x2F;hike 20-30 miles&#x2F;week. I&#x27;m 6&#x27;1, 240 lbs, large frame. I&#x27;ve been on a diet basically my whole adult life, except for when I start a new job, in which I always gain weight because I don&#x27;t want to be hangry and I put the job first. Then I spend the rest of the tenure at that job trying to lose it.<p>For years, I&#x27;ve had zero unhealthy food in the house, and my biggest cheat has been an occasional breakfast burrito, or a medium sandwich and some ice cream after a long walk. That&#x27;s been enough to not gain weight, but not enough to lose any more than 5-10 lbs, which I gain back over the holidays every year.<p>Anyway that&#x27;s just my story. I suspect I&#x27;m a pretty big outlier in the amount of exercise I get and the habits I already had. I have enough in my HSA to afford about a year. I&#x27;m hoping to lose a bunch, snap back the usual 10 lbs or so, then stabilize.
slashtom11 个月前
How much of this is just the fact that alcohol is typically &#x27;banned&#x27; from patients taking this drug?<p>Sorry didn&#x27;t read too much into it but are they testing the reduction specifically for alcohol addiction or was alcohol addiction measured from people currently taking it for weight-loss&#x2F;diabetes?
评论 #40566402 未加载
nunez11 个月前
Semaglutides are the AI of the medical field right now. Every press release that drops about them seems to be about how _even more_ transformative it is. Crazy stuff if the side effects of this drug become manageable and no long-term side effects appear.
mise_en_place11 个月前
Ozempic and Metformin stack is a cheap anti-aging regimen. Although you may need to add B12 as both seem to affect B12 levels and cause B12 deficiency. Methylated B12 intravenous or stacking the injection w&#x2F; B12 will alleviate this problem.
sibeliuss11 个月前
What are the typical effects of someone stopping the drug abruptly? Have those been studied?<p>I worry that it might result in a resumption of previous patterns of behavior, yet with an additional ferocity.
评论 #40565440 未加载
评论 #40565737 未加载
评论 #40565540 未加载
DoreenMichele11 个月前
Makes me wonder what the mechanism is. Some drug that treats depression also helps people quit smoking. It treats a specific brain chemical not treated by some depression drugs.
alexb_11 个月前
So how long is it until we start putting this in the water?
评论 #40568130 未加载
odiroot11 个月前
Will there be a heavy lobbying from fast food, sweetened drinks, alcohol etc industry to ban this drug? One wonders.
评论 #40565809 未加载
评论 #40566444 未加载
kingkawn11 个月前
Mess with the fundamental hormonal balance honed over the eons of hunger and survival? What could go wrong?
评论 #40565436 未加载
评论 #40565388 未加载
评论 #40565764 未加载
评论 #40565380 未加载
评论 #40565602 未加载
评论 #40565361 未加载
评论 #40565711 未加载
评论 #40565756 未加载
KittenInABox11 个月前
I&#x27;m really interested if, in the future, obesity will be treated like alcohol-induced fatty liver, track marks, and other medical signs of addiction and not some kind of moral failure on the obese person. This also tracks with knowing addiction can sometimes be caused by childhood trauma (obese people are more likely to be traumatized as kids), genetic predisposition(obesity runs in families), and neurodevelopmental diseases like ADHD (obesity prevalence higher in people with ADHD).<p>In this view obesity is more like a tragic compulsion resulting from things out of a fat person&#x27;s control and not some kind of &quot;put down the cheeseburger sometime&quot; activity to willpower onesself out of.<p>EDITED: Hey, am I saying something wrong or irrelevant here? (sitting at -3, but I don&#x27;t think I&#x27;ve been particularly inflammatory or offtopic)
评论 #40565562 未加载
评论 #40565824 未加载