Microbiome composition varies based on sampling time, mouse study finds

I suspect chronomicrobiomics will be one of the next trends with wellness gurus given that newer research may take timing into consideration whilst a lot of prior research doesn't.

This study found that the microbiome composition varies based on the time of sampling. How do you think this variability might affect the reproducibility of microbiome research? What are some practical ways researchers could standardize sampling times to improve consistency across different studies?

If sampling time is effecting mice, good luck with Human Studies. It is not easy to get human gut microbiome samples in clinical trials especially when they are already suffering from disease. Even with longitudinal studies, patients can skip donating samples. Making it difficult to compare. Also diet (big factor) and genetics can impact your microbiome. Having said that, I am big fan of longitudinal microbiome studies with good metadata collection such as time of sample collection, Bristol stool scale, and diet(this is very difficult to quantify).