I’m very sorry to hear this - I lost my wife a year ago to metastatic melanoma and it was both awful and particularly cruel as she had hope, which was ultimately dashed.<p>Try to consult with a big cancer center like MSK, Dana Farber, MD Anderson, etc perhaps there’s a trial that would be helpful with CART or similar therapy, although it sounds like you pursued this route. Stay away from the internet cures and tune out well meaning friends with vitamins and nonsense.<p>Also, you don’t want to hear this, but you need to be prepared for an undesirable outcome and think about the comfort and life your relative will live. My wife went through 3 brain surgeries, did well and was walking around the streets of NYC, happy, celebrating moving to the next phase. 3 days later, she died due to an unexpected complication. I miss her terribly, but we somehow had fun traveling hundreds of miles for cancer treatments, i wouldn’t give that up for anything.<p>Also, take care of yourself. Talk to someone, a therapist, priest, friend, stranger, partner, etc. In my professional and personal life, I’m the guy that makes problems go away. I can be a cocky bastard sometimes. With cancer, you’re fighting math, and sometimes no matter what you do you can’t assert the control that you feel you can and the outcomes are out of your hands.<p>Good luck and please be well.