Covid-19 Intranasal Vaccine

Pretty impressive, if true that it can stop infection, and potentially then transmission. Nasal vaccines have the ability to do this because of the potental for neutralizing activity along the nasal muscosa.<p>They make the claim so we&#x27;ll have to see. I currently use a nitric oxide nasal spray as the nose is the major area to protect (and also use probiotic lozenges of the k12 strain for the throat).<p>--- “The vaccine offers potent protection against transmission, prevents reinfection and the spread of the virus, while also reducing the generation of new variants,” Dr Liu said.<p>“Unlike the mRNA vaccine which targets only the spike protein, CDO-7N-1 induces immunity to all major SARS-CoV-2 proteins and is highly effective against all major variants to date.<p>“Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.” ---

&gt; “Unlike the mRNA vaccine which targets only the spike protein, CDO-7N-1 induces immunity to all major SARS-CoV-2 proteins and is highly effective against all major variants to date.<p>&gt; “Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.”<p>This being a more traditional vaccine, I wonder if any vaccine hold outs will be more receptive

Very cool! Are there other vaccines that have been formulated for mucosal ingestion? What makes that delivery method so effective?

IIRC there were several nasal vaccines at this same stage in development before. Apparently the bottleneck is getting acquired to get enough funding to do the big expensive trials for regulatory approval.

&gt; Twitter formerly known as X<p>Given that X is the new name, should it not be &quot;X formerly known as Twitter&quot;?

It sure would have been nice if there was a quality intranasal vaccine that the government could have shipped to each household instead of the insane goose chase that was trying to get vaccine appointments.

There was talk about intranasal vaccines against Covid in 2020 already. But there was a catch: they need to be tested really, really well.<p>Anything that gets snorted into your nose has a pretty short path to the brain, with potentially &quot;interesting&quot; results (cocaine, Naegleria fowleri etc.). So you have to be extra sure that your intranasal medication is harmless.<p>As the article mentions, this particular vaccine has been developed for four years. That seems to be long enough to be sure. But I wouldn&#x27;t be taking it back in 2021 or 2022.

&gt; “Importantly, the vaccine remains stable at 4°C for seven months, making it ideal for low- and middle-income countries.”<p>That&#x27;s it&#x27;s best feature, not the nasal administration IMO.

&gt; up to a year or more<p>So, literally any amount of time?

Don&#x27;t live-attenuated vaccine viruses evolve, with a potential to restore their original virulence? Example: Sabin&#x27;s polio vaccine.

This is great! When can I get it?

does anyone know what stage this is in and what the path forward\timeline would be?

&quot;in mice, hamsters, and macaques&quot;

Is COVID-19 still an issue considering that there has been only 1151 new cases in the US, and 68 in India, and 73 in Germany yesterday? &quot;Only&quot; 7 people died out of these 1151 people in the US, and we do not know the details, I am assuming old age, compromised immune system, comorbidity, etc.