I haven't read the CELL paper yet (would love to, if somebody has a PDF to share).<p>But I'm surprised I yet haven't seen a mention of Dr. Michael Greger's book [1] <i>How Not to Die</i>, which does an excellent job of elaborating how various diseases -- including cardiovascular diseases, diabetes, etc -- result in death.<p>I found it immensely helpful in plugging a lot of holes in my understanding of my own health (FWIW: 40s, no chronic diseases, but tendency towards high(er) A1C, cholesterol)<p>He has subsequently released other books -- How Not To Age, How Not to Diet, etc -- which one might call as capitalizing on the trend, not to put too fine a point on it. [However, I do find his books, videos and discussions quite informative, and not too technical, without going into the hyper-masculine, pseudo-science-y word salad territory waded into by, say, Huberman.]<p>There's a brief video [2] on side effects of metformin as a life extension drug, which seems relevant to the CELL paper above.<p>[1] <a href="https://nutritionfacts.org/book/how-not-to-die/" rel="nofollow">https://nutritionfacts.org/book/how-not-to-die/</a>
[2] <a href="https://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug/" rel="nofollow">https://nutritionfacts.org/video/side-effects-of-metformin-a...</a>