Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

For the group, because I can never keep the terms straight:<p>Semaglutide is one specific drug within the class of GLP-1 agonists. Other examples include Liraglutide (Victoza, Saxenda), Dulaglutide (Trulicity), and Tirzepatide (Mounjaro, though this is technically a dual GIP&#x2F;GLP-1 agonist).<p>Semaglutide is available under several brand names for different uses: Ozempic (type 2 diabetes), Wegovy (weight management), and Rybelsus (oral form for type 2 diabetes).

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it.<p>The number of things it apparently just <i>cures</i> is staggering.

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

This would be <i>amazing</i> if true, but the lack of randomization makes me nervous. What if, like, patients who are about to get Alzheimer&#x27;s are less aggressive about asking their doctor for semaglutide (which has been in shortage for a while), and that explains the trial results?

&gt; nationwide database of electronic health records (EHRs) of 116 million US patients.<p>If you are expert in this space: Is such a dataset available publicly? If so, are there examples of other studies that have used this? Where does one go to read more about the mechanism of this study? Thanks!

According to this article, it&#x27;s been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible.<p>Given that, I&#x27;d want to see more reproductions.<p>Also, I&#x27;m very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

TL;DR from the article: The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one of the seven other diabetes drugs. The results were consistent across gender, age and weight.<p>The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimer’s, the study found.<p>Full link to the study itself: <a href="https:&#x2F;&#x2F;alz-journals.onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1002&#x2F;alz.14313" rel="nofollow">https:&#x2F;&#x2F;alz-journals.onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1002&#x2F;alz...</a>

<a href="https:&#x2F;&#x2F;www.sciencedirect.com&#x2F;science&#x2F;article&#x2F;pii&#x2F;S2589537024003055" rel="nofollow">https:&#x2F;&#x2F;www.sciencedirect.com&#x2F;science&#x2F;article&#x2F;pii&#x2F;S258953702...</a>

How long has Ozempic been around? I&#x27;ve never heard of it until very recently (maybe the last month or two) and suddenly I&#x27;m seeing it all the time. Maybe this is an instance of Baader-Meinhof phenomenon, but it doesn&#x27;t feel like it.

Finally, pharma is paying for studies showing the advantages of not being obese.

Is it the ozempic or just the healthier weight &#x2F; lower calorie intake?

Get skinny and keep my brain? No thanks. At some point this roller coaster ride needs to end.

I actually am on ZepBound, and it&#x27;s great, only I just heard that my coverage is going away. I&#x27;m gonna pay the $650 &#x2F; month and suck it up.<p>Disgusting.

Oh Oh Oh Ozem...I forgot the rest

Why not just lose weight by eating less? I know that sounds like a dumb question.<p>But genuinely, aren’t you just paying money to… not spend the money on food instead?