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GLP-1 for Everything

150 点作者 etiam7 个月前

17 条评论

kbos877 个月前
The best way that I can describe what Semaglutide has done for me is that I feel like almost nothing in my life has changed (other than being down 45lbs, suddenly having normalized liver enzyme levels and blood pressure.) Before starting it, I generally ate until I was satiated, almost never over full. From time to time I&#x27;d maintain a caloric deficit, but it meant a large part of my attention was consumed, day and night, by a nagging distraction of food.<p>Today, I still just eat a normal diet until I&#x27;m satiated - but 1&#x2F;3 of the food is left on the plate. I have a little less of an interest in alcohol and coffee, but other than that it&#x27;s like nothing has changed.<p>My point is that there&#x27;s still a common sentiment that these drugs are some sort of a shortcut for people who want the ability to over-indulge, when in reality that couldn&#x27;t be further from the truth.<p>I think what I feel like on a GLP-1 is what most people feel like without one. If you want to know what I feel like without a GLP-1, try not eating until your mind is constantly nagging you to do so - then try staying like that forever. That&#x27;s what a lot of people propose to anyone who has a problem with their weight.
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kelseyfrog7 个月前
The main difference between GLP-1 agonists and telling people to eat less&#x2F;better is that one works and one doesn&#x27;t.
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jpadkins7 个月前
I haven&#x27;t seen any comments on the topic of chronic inflammation. I am not knowledgeable on this topic, but we do know that chronic inflammation is linked to a huge number of disease end points. GLP-1 may be reducing (or preventing) systemic inflammation.<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Systemic_inflammation" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Systemic_inflammation</a>
brvRXZ6 个月前
GLP-1 seems to inhibit the production of glucagon, which should directly reduce the amount of glucose in blood, which is a desired effect for treating obesity. On the other hand, it seems to stimulate insulin production, which also reduces glucose, but extra insulin may cause insulin resistance, which can contribute to type II diabetes. Insulin resistance can take years to develop, so maybe you should test for that if you use GLP-1 long term.
avelis7 个月前
&gt; FTA: So we&#x27;re not only going to be treating (or outright preventing) a number of diseases, we&#x27;re going to be learning more about the cause of these diseases than we ever did before.<p>Ultra processed foods (UPF) needs a hard look IMO. It&#x27;s the leading cause of many diseases stated in the article and several others including cancer and dementia.
devit7 个月前
What about people who, with their current habits, are on the bottom range of what is considered &quot;normal&quot; weight (in the BMI sense) or already underweight?<p>Wouldn&#x27;t taking GLP-1 agonists (for potential non-weight-loss benefits) be potentially harmful as it may reduce eating even further and lead to being significantly underweight?
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andrewmcwatters7 个月前
It feels more likely to me that there&#x27;s some sort of condition we don&#x27;t have a widely known name for that is caused long-term by a combination of predisposition in genetics and something in western diets that is, I&#x27;m not sure, forcing us to overproduce ghrelin (possible links to puberty occurring earlier in both young boys and girls?), or underproduce certain classes of incretins (possible links to excessive blood sugar levels in larger percentages of the population historically over time?).<p>It would be boring to learn that it&#x27;s just caused by excessive exposure to fructose.<p>But what do I know, I&#x27;m just a dumb HN reader.<p>Seems neat that there&#x27;s ongoing work in this area and it&#x27;ll be cool to read about new knowledge in that space when something is discovered.
explodingman7 个月前
Love that word &quot;pleiotropic&quot;, nice vocab builder.<p>So it looks like GLP-1 may have positive side-effects beyond what can be explained as consequences of weight loss. Surprising linkages between biochemistry&#x2F;hormones and temperament.<p>I am slowly (1 kilogram per month) losing weight by eating nothing but meat 2-3 days per week. My understanding is that the extra GLP-1 secreted by the gut when digesting lots of protein leads to appetite suppression. It works, and is surprisingly easy to do (no feelings of hunger).<p>So will I also be getting the beneficial side effects of GLP-1? If so, high-protein dieting becomes the smart way to lose weight.
levocardia7 个月前
Color me a bit skeptical on the &quot;GLP-1 is the cure for everything&quot; hype. These drugs are clearly a game-changer for obesity and T2D, and possibly a few other conditions, but it strikes me as unlikely that a chemical exists that is more or less an across-the-board improvement to health, with no downsides. If it was that simple, why didn&#x27;t the human body just evolve to excrete GLP-1 agonists? Or modify GLP-1 itself?<p>The best argument against is &quot;starvation was a human universal&quot; and that survival through famines totally dominated the evolutionary trend in GLP-1 related things in the body. But even something as simple as lactose tolerance responded quite quickly to changes in human dietary structure in different areas of the world.<p>My suspicion is that at least some of these medical record review studies are just driven by confounding - people who find out about GLP-1 agonists are better educated, wealthier, or have behavioral&#x2F;lifestyle traits that explain many of the apparent benefits.<p>(still, part of me is still holding out for the &quot;miracle drug&quot; explanation)
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cschmidt7 个月前
This exact line of reasoning is the cover story on the Economist this week:<p>Briefing: <a href="https:&#x2F;&#x2F;www.economist.com&#x2F;briefing&#x2F;2024&#x2F;10&#x2F;24&#x2F;glp-1s-like-ozempic-are-among-the-most-important-drug-breakthroughs-ever" rel="nofollow">https:&#x2F;&#x2F;www.economist.com&#x2F;briefing&#x2F;2024&#x2F;10&#x2F;24&#x2F;glp-1s-like-oz...</a><p>Leader (opinion piece): <a href="https:&#x2F;&#x2F;www.economist.com&#x2F;leaders&#x2F;2024&#x2F;10&#x2F;24&#x2F;its-not-just-obesity-drugs-like-ozempic-will-change-the-world" rel="nofollow">https:&#x2F;&#x2F;www.economist.com&#x2F;leaders&#x2F;2024&#x2F;10&#x2F;24&#x2F;its-not-just-ob...</a><p>(sorry, paywalled)
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dyauspitr7 个月前
This is probably what’s going to get us over the 80 years life estimate plateau. The main killers now are overwhelmingly cardiovascular diseases and cancers.
mentos7 个月前
Isn’t this just eating less food is good for everything?
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milliams7 个月前
What&#x27;s GLP-1?
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bartwr7 个月前
It&#x27;s interestingly disingenuous that many claim of GLP-1 agonist miraculous effects on all kinds of health problems, where the same problems are &quot;simply&quot; solved by getting on a calorie deficit and lean. Liver, kidneys, heart, etc. If you have a non-alcoholic fatty liver disease and are obese, getting leaner will heal it. All those impressive results are on obese or diabetic people. So it is not only not a surprise, but also dishonest marketing or ignorance.<p>Don&#x27;t get me wrong - those are miraculous drugs. First real non-stimulant low side effect appetite suppresion that will help millions. But let&#x27;s wait for honest research on <i>lean</i> people before spreading marketing on how it improves overall health.<p>Also, how nobody mentions the need for increasing the dosage and tolerance build-up (just check reddits how much people end up having to take after months of continuous use). You cannot be on it &quot;for life&quot;.
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erulabs7 个月前
Born too late to die in infancy, born too early to see immortality.<p>I imagine parents in the 1890s felt the same way. Our children will see a new and different world than we can imagine. I love this topic of moving past “health” and towards something better. To quote an 1890s thinker: “it’s time to find out what value our values really had”.<p>This does remind me of the superconductor stuff tho - I’m too excited - it will be interesting to see what focused clinical studies show us here, particularly around GLP-1’s effects on addiction.
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haccount7 个月前
Guys hear me out. The next VC funded killer idea:<p>ChatGLP!
riwsky7 个月前
I used GLP-1 to prepare my taxes last week, it was such a stress-free experience.<p>Then as I was coding I kept hitting context window limitations with o1-preview. so on a lark I just fired up my local Ozempic and submitted the same prompts and bam: spit out a whole working iOS app first try.<p>I heard that before they nerfed it with RLHF, Mounjaro not only treated diabetes but also made you charming in conversation and sublimely compassionate towards all beings.<p>The future is now