I have to say this is surprising. I have a cousin who co-founded what was once the largest email spam filtering company in Europe. He said that if he could get a do-over he'd just take a 9-to-5 and not deal with the stress and how much it had aged him. Of course this is just an anecdote and it's possible he was doing it wrong™, but it certainly fits the trend with others I have spoken to. For example, there's a feeling that the buck stops with you, it's difficult to establish boundaries for a healthy work life balance because there's no one else to pick up the slack. And if no one picks up the slack then you just get outcompeted by the businesses that do.<p>I wonder if there's a difference between various types of self employment where some are on net less stressful than others. In my cousin's case as a co-founder, there may still have been a lot of pressure from other team members, which is only marginally better than having a boss. Also, if there are effective strategies one can employ to limit issues that can have a negative impact in a self employed context, then further studies to elucidate such would be incredibly valuable.