It is a sad goal, not only because of the loss of enjoyment, but also because the "trip" is a significant part of what brings the benefits.<p>The introspective experience of viewing oneself, and one's relation to the rest of the world, from a unique perspective, is a key part of what brings the benefits.<p>The other, unmentioned, benefit of making a custom version of a common pharmaceutical chemical, is the ability to then patent the result. Thus granting the "inventor" a near permanent exclusive right to the drug.