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Mitochondria as you've never seen them

343 点作者 Brajeshwar4 个月前

25 条评论

LinguaBrowse4 个月前
I studied an BSc in genetics and none of our lectures or textbooks presented mitochondria any differently from the classic bean shape they introduce in school. This is surely old news to folks who specialise in mitochondria, but it&#x27;s easy to miss out on these fundamentals even if you&#x27;ve studied in a relevant area at degree level, because there&#x27;s just so much to know in biology.<p>In fact, it&#x27;s one of those fields where the more you learn, the more you realise we&#x27;ll never reach a satisfactory understanding in our lifetime. You could chuck an endless supply of PhD students at every constituent domain for generations and still feel like you&#x27;ve scarcely scratched the surface of the many things there are to question.
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bentt4 个月前
Mitochondria are a descendant of early bacteria which infiltrated an Archaea cell, traded genes, and started replicating with it, forming a new organism about 1.5bn years ago.<p>The wild part is that all mitochondria are descended from that single event.<p>This was a rather controversial theory called Endosymbiosis and it was pioneered by Lynn Margulis. Now it is widely accepted.<p><a href="https:&#x2F;&#x2F;evolution.berkeley.edu&#x2F;it-takes-teamwork-how-endosymbiosis-changed-life-on-earth&#x2F;evidence-for-endosymbiosis&#x2F;" rel="nofollow">https:&#x2F;&#x2F;evolution.berkeley.edu&#x2F;it-takes-teamwork-how-endosym...</a>
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gcanyon4 个月前
Does anyone here have a sense of what time frame the video covers? Like, is that real-time and mitochondria are continuously mildly active? Is it vastly slowed down and mitochondria are ripping around in our cells like madmen? Is it vastly sped up and mitochondria are actually relatively static, slow movers?
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8-prime4 个月前
Mitochondria are so absurdly more complex and interesting than what is mostly taught in schools. Awesome video!
Madmallard4 个月前
Really sucks that antibiotics, especially bacteriocidal ones, appear to target mitochondria as if they were bacteria. This mistargetting causes sometimes severe and long-lasting side effects.
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kgc4 个月前
So each of our cells is a habitat for a network of wiggly energy-producing worms...
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tosser00014 个月前
Even the Wikipedia entry on them has the classic bean-shaped diagram. If they are not really like that, why did that become the standard representation? Have they always been know to exist in more network-like structures, and was that why there was initial resistance to seeing their origin in free-living prokaryotes?
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j16sdiz4 个月前
It came from NIH&#x2F;NIGMS public archive: <a href="https:&#x2F;&#x2F;images.nigms.nih.gov&#x2F;pages&#x2F;DetailPage.aspx?imageid2=6967" rel="nofollow">https:&#x2F;&#x2F;images.nigms.nih.gov&#x2F;pages&#x2F;DetailPage.aspx?imageid2=...</a>
kylebenzle4 个月前
Wow! Really shows how mitochondria are actually just bacterial cells living inside us!
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ravenstine4 个月前
&gt; Powerhouses of the cell<p>Will we ever get away from this cliche? I loathe it because it&#x27;s not only a cliche but I don&#x27;t believe it actually helps the lay person understand the role of mitochondria. It&#x27;s not completely inaccurate since they&#x27;re effectively refining energy substrates (fat, glucose) into ATP by converting ADP in the TCA cycle; ATP becomes ADP again from energy expenditure and the cycle repeats, to oversimplify things. Are we adequately teaching people that mitochondria don&#x27;t create or release (utilizable) energy? I kind of doubt it. But maybe I&#x27;m just annoyed from hearing that descriptor a bajillion times starting from middle school.
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tannerrennat4 个月前
This makes me want to further explore the similarities in form and function of mitochondrial networks and mycelial networks.
siva74 个月前
So beautiful and so sad to think about how much more interesting biology is than what we can teach from textbooks.
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justinator4 个月前
To think I&#x27;ve spent hours upon hours each week for years and year with the express goal of producing more of these in the muscle cells of my legs, and I call this novel goal &quot;exercise&quot;.
adzm4 个月前
Madeline L&#x27;Engle was right all along
esbranson3 个月前
Professor Burnette makes videos and other things. Very cool stuff.<p><a href="https:&#x2F;&#x2F;x.com&#x2F;MAG2ART" rel="nofollow">https:&#x2F;&#x2F;x.com&#x2F;MAG2ART</a>
pulkitsh12344 个月前
Mitchondria may also help us keep time: <a href="https:&#x2F;&#x2F;www.quantamagazine.org&#x2F;what-makes-life-tick-mitochondria-may-keep-time-for-cells-20230918&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.quantamagazine.org&#x2F;what-makes-life-tick-mitochon...</a>
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efitz4 个月前
In the video, the mitochondria appeared to be motile. Are they?
yieldcrv4 个月前
Without this symbiotic relationship in cellular life on other planets, would it prevent complex cellular life?
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meerita4 个月前
I love the Roman Bath photos!
tetris114 个月前
The Seven Daughters of Eve are alive and well, I see
NHQ4 个月前
I want to see the frame data and rendering code.
p3rls4 个月前
Is the link supposed to go to a slideshow?
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iancmceachern4 个月前
This is incredible
baruchel4 个月前
By coincidence, today&#x27;s xkcd comic matches this topic perfectly! <a href="https:&#x2F;&#x2F;xkcd.com&#x2F;3046&#x2F;" rel="nofollow">https:&#x2F;&#x2F;xkcd.com&#x2F;3046&#x2F;</a>
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breck4 个月前
There are shockingly few images of mitochondria available online.<p>I started a project to increase that number by 1,000,000x: <a href="https:&#x2F;&#x2F;powerhouse.breckyunits.com&#x2F;" rel="nofollow">https:&#x2F;&#x2F;powerhouse.breckyunits.com&#x2F;</a><p>I&#x27;m currently mastering the same confocal fluorescence technique used in this image (but borrowing microscope time, as the scope costs &gt;$250K), but also developing an at-home protocol using Janus Green that should cost less than $200.
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