World-first experimental cancer treatment paves way for clinical trial

It's neo-adjuvant (treat prior to surgery) with a three mAbs: Ipi + Nivo, which is a well established combo of immunotherapeutics for many solid tumors, rounded out with relatlimab which I'm less familiar with (LAG-3 inhibition). Neoadjuvant use of immunotherapies is established concept and is utilized in clinical practice for non-small cell lung cancer and colon cancer. This is the first time I've seen a use of 3 immunotherapies used at once: Ipi + Nivo isn't the most tolerable treatment regimen. Other novel aspect is use of neoadjuvant therapy in GBM.

I would like to see a clinical trial with patients who have Stage 4 disease being treated with multiple immunotherapies, up to 5 or 6 IV and oral immunotherapies. Why are we holding back in a population with poor prognosis??<p>As far as legislation, we should pass &quot;Right to Try&quot; laws. Allowing anyone with Stage 3 or 4 to pick an immunotherapy regardless of whether it&#x27;s been approved. We should never allow hope to die!

Presumably this is the Richard Scolyer case, if anyone was curious.<p>A brief lookup indicates he could possibly be seeing recurrence; hopefully that&#x27;s not the case but this is something that many people have said about his trial. We can&#x27;t say for sure this treatment is going to be broadly effective without more time and experiments.

How is this the “first experimental cancer treatment” ?<p>It’s not. Of course.<p>It may be the first triple immunotherapy (3 checkpoint inhibitors), given in a neo-adjuvant setting, in glioblastoma.<p>Still cool, less catchy<p>(Or maybe I don’t understand “world-first” ?)

I&#x27;m not a fan of stuff in very early stages like this being posted

This might be related with the case of Richard Scolyer, the Australian pathologist diagnosed with Glioblastoma. He was receiving some kind of experimental treatment for it.

This is hopeful news for a really tragic cancer.

This is fantastic news, glioma treatment progress was stagnant for a long time and is finally starting to pick up steam.

It&#x27;s not a generic novel treatment against any and all cancers, as much as the headline would lead you to conclude.

I&#x27;m wondering though if this research and clinical trials has had their funding threatened recently.

This could be groundbreaking I guess! :)

Disappointed this wasn&#x27;t about Venus

It cant be coincidental that this news with a misleading headline is being pushed right at the time when a revolutionary Chinese drug changed the landscape.