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Bispecific antibodies potently neutralize SARS-CoV-2 variants of concern

370 点作者 ohjeez3 个月前

8 条评论

sharpshadow3 个月前
Sadly that reminds me how positive covid antibody test results haven&#x27;t been a valid immunization attestation.<p>Maybe this type of bispecific antibodies could be used to neutralize the spike protein which the body produces through the vaccine. As far as I understand the targeted deltoid muscle is a cell with a long life therefore procuding and releasing spikes for a yet unkown timeframe. Given the various specific boosters I can imagine one taking neutralizing antibodies to avoid a constant immune system stimulation.
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kens3 个月前
The title is &quot;Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern&quot;. Note that although the antibodies were only helpful before infection, &quot;its therapeutic efficacy after infection was limited.&quot; Thus, it isn&#x27;t a treatment. Also, this study was in mice, not humans, so this is something potentially for the future, not something you can use now.
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mkoryak3 个月前
What does this mean? A better vaccine?
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countWSS3 个月前
All variants? but N-Terminal is not immune to mutations and the specific antibody will drive evolutionary selection for those mutations - and rapid development of new variants<p><a href="https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC8647783&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC8647783&#x2F;</a> search &quot;N-Terminal&quot;
bogtog3 个月前
I&#x27;m amazed by how virtually every single biology paper in a great-to-elite journal has stunning figures (even setting aside the protein diagrams). This makes me wonder how much of advisors&#x27; efforts go toward teaching their students graphic design
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jonlucc3 个月前
Also of note because of recent political choices, these are humanized mice, meaning they&#x27;re transgenic. They have a human ACE2 gene instead of the mouse ACE2 gene, which makes the human version of the enzyme that the COVID virus uses to enter cells. This isn&#x27;t my exact field, so I&#x27;m not positive, but I remember hearing that all of the COVID mouse models require transgenic mice.
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tomrod3 个月前
Sign me up!
petesergeant3 个月前
Needs an [in mice] tag
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