CDC pages on histoplasmosis are still up for the time being:<p><a href="https://www.cdc.gov/histoplasmosis/about/index.html" rel="nofollow">https://www.cdc.gov/histoplasmosis/about/index.html</a><p>Fungal meningitis of all kinds (not just histoplasmosis) is hard to treat. Simply because of phylogenetic relationships, most compounds that target fungal cells are also pretty nasty to our own cellular physiology.<p>Our arsenal of anti-fungals is quite limited drug resistance to our most commonly used drugs (azoles) evolves rapidly in most fungi. Unfortunately, azoles are also widely used in agriculture (to combat plant fungal pathogens) and there are many drug-resistant lineages of common opportunistic pathogens such as Aspergillus and Candida "at large".