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Cure ID App Lets Clinicians Report Novel Uses of Existing Drugs

72 点作者 throw0101d大约 1 个月前

6 条评论

mdip大约 1 个月前
Interesting ... it&#x27;s presented in the context of drugs for curing infections.<p>I wonder if this is being used for other drugs. My curiosity stems from personal experience: I had Migraine headaches from age 17 to about 35. I was put on ancient seizure medication that&#x27;s common prescribed for Bipolar[0] because this doctor had three other patients that it nearly eliminated Migraine from. It was fall, a time when I&#x27;d get about one a week. After five days of taking it, I had my first Migraine ... if you could call it that -- I could only identify that it <i>was</i> a Migraine by the aura; the pain was about 10% what I&#x27;m used to).<p>Searching through the web, I found a forum that was filled with Migraine sufferers. Sure enough, there were a handful of people who <i>swore</i> by it. There were also a handful of people who it didn&#x27;t work for. Looking at the more official sources, there was no indication that this drug could have <i>any</i> effect on Migraine; they listed all of the <i>other</i> off-label uses[1], but Migraine was not among them.<p>This medication had been in the news several times (and on the front page, here[2]) over the last few years and a year ago (or so), I looked it up on the &quot;official sources&quot;, again. It now indicated that it was prescribed for Migraine.<p>It made me wonder ... how are things like that figured out&#x2F;communicated down-stream? Is it entirely informally amongst doctors? I went to four different specialists before I found one who suggested this drug -- and he did so in a &quot;half-hearted manner&quot; not truly expecting it would work. It&#x27;d be nice if this was centrally tracked&#x2F;managed as it might surface both &quot;new uses for old drugs&quot; and &quot;new problems with old drugs.&quot;<p>[0] Which I do not have.<p>[1] It&#x27;s rarely, if ever, prescribed for what it was originally approved for.<p>[2] It&#x27;s Depakote, I&#x27;m not being cagey for nefarious purposes, I just didn&#x27;t want this to be a drug advertisement.
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navan大约 1 个月前
Just today I read about this in the book &quot;Who is Government&quot; by Michael Lewis where he presents the case on how it can help find cure for rare diseases. You can read his article at <a href="https:&#x2F;&#x2F;www.washingtonpost.com&#x2F;opinions&#x2F;interactive&#x2F;2025&#x2F;michael-lewis-fda-who-is-government&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.washingtonpost.com&#x2F;opinions&#x2F;interactive&#x2F;2025&#x2F;mic...</a>.<p>Also highly recommend the book.
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shreezus30 天前
There are so many interesting, off-label novel uses for drugs that have already been developed. Recently my wife &amp; I adopted a kitten that developed FIP, a disease caused by a feline coronavirus that was nearly 100% fatal up until just a few years ago.<p>Turns out, a drug developed by Gilead Sciences (GS-441524) which is the active metabolite of remdesivir, is remarkably effective at treating the disease. It&#x27;s a nucleoside analog, so it essentially is a slightly modified adenosine molecule which disrupts the virus RNA replication process.<p>Within 12 hours of the first dose our cat went from dying to making a full turnaround and complete recovery following treatment. For us it was truly a miracle drug, and it only gained awareness recently due to the COVID-19 pandemic [1]. It still isn&#x27;t technically &quot;approved&quot; for this use case, but is prescribed off-label by vets as of 2024 once the FDA relaxed its position [2]. Folks needed to seek it out on the black market (and still do in some areas).<p>[1] <a href="https:&#x2F;&#x2F;www.theatlantic.com&#x2F;science&#x2F;archive&#x2F;2020&#x2F;05&#x2F;remdesivir-cats&#x2F;611341&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.theatlantic.com&#x2F;science&#x2F;archive&#x2F;2020&#x2F;05&#x2F;remdesiv...</a><p>[2] <a href="https:&#x2F;&#x2F;www.fda.gov&#x2F;animal-veterinary&#x2F;cvm-updates&#x2F;fda-announces-position-use-compounded-gs-441524-treat-fip" rel="nofollow">https:&#x2F;&#x2F;www.fda.gov&#x2F;animal-veterinary&#x2F;cvm-updates&#x2F;fda-announ...</a>
CharlieDigital30 天前
Very cool seeing this show up on HN. FDA has a bunch of interested datasets like this that are full of interesting data points.<p>During COVID, I actually wrote a small sample app that pulls info from this DB: <a href="https:&#x2F;&#x2F;www.covidcureid.com&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.covidcureid.com&#x2F;</a><p>And gave a talk on it: <a href="https:&#x2F;&#x2F;learn.microsoft.com&#x2F;en-us&#x2F;shows&#x2F;azure-serverless-conf&#x2F;surfacing-fda-covid-data-using-serverless-functions-and-cosmosdb-with-charles-chen" rel="nofollow">https:&#x2F;&#x2F;learn.microsoft.com&#x2F;en-us&#x2F;shows&#x2F;azure-serverless-con...</a>
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adamredwoods大约 1 个月前
I wonder how this is going (started 2013), because I have a hunch it will be chasing ghosts, mostly. Placebo affect is a factor here. I also wonder how many fake leads from &quot;propaganda physicians&quot; they get.
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jjtheblunt大约 1 个月前
&quot;Content current as of: 06&#x2F;08&#x2F;2020&quot;