> yet it crashed spectacularly in Phase III clinical trials.<p>I don't think this necessarily means the approach is flawed: my understanding is that the value these companies/models try to deliver is that it brings down the search space of molecules you test in your funnel by several order of magnitude.<p>Some will still fail, but as long as you do better than how things used to be done before, you bring value.<p>Maybe it will just take one blockbuster success for Pharma companies to decide this approach is worthwhile.