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Why our waistlines expand in middle age: aging stem cells shift into overdrive

82 点作者 gmays12 天前

5 条评论

its_down_again12 天前
The current title “How aging stem cells fuel visceral fat gain in middle age” suggests that existing stem cells simply ramp up fat production as they age.<p><i>Single-cell RNA sequencing of APCs then identified a new committed preadipocyte population that is age enriched (CP-A), both in mice and humans. CP-As displayed high proliferation and differentiation capacities, both in vitro and in vivo.</i><p>It should read more like &quot;aging triggers emergence of a specific stem cell type (APCs) which drives visceral fat expansion&quot;
01HNNWZ0MV43FF12 天前
&quot;overdrive&quot; isn&#x27;t a good metaphor most of the time<p>Let&#x27;s say they &quot;hit the nitro&quot; (not turbo!) or &quot;floor it&quot; or &quot;give it the beans&quot;
wonderwonder12 天前
Gaining weight and keeping it is a choice. There are a myriad of solutions some simple like diet and exercise, some more complex like TRT and glp-1 drugs.<p>I gained a good amount of weight since I had kids, went from a healthy weight of 210lbs at 6&#x27;1 to 240lbs at 45 years old.<p>I always worked out so I had good muscle mass but my diet was terrible, often consuming a pint of ice cream at night once the kids went to sleep.<p>I got on TRT and compound semaglutide and now I am 215lbs with abs and in the best shape of my life. I recently benched 405lbs at 46 years old. Prior to this I could do 2 pull ups if I was lucky I can rep 10 - 15 now. My stress levels are down, my blood pressure is in a healthy range for the first time in decades. I go to the gym 5 days a week, sometimes 6 and I love it. There are always solutions, we don&#x27;t have to accept a slow decay.
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xvilka12 天前
A possible solution would be some kind of viral therapy - a custom virus to target adipocytes. Similarly how it&#x27;s done [1] to some cancer cells.<p>[1] <a href="https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Oncolytic_virus" rel="nofollow">https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Oncolytic_virus</a>
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RacingTheClock12 天前
The more there is research into how fat actually works as a tissue the more I suspect CICO is a harmful oversimplification along the lines of just say no to drugs or abstinence-only sex education.
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