I'm a summer intern at Khan Academy working on various App Engine projects. My uneducated guess is that we're one of the platform's bigger customers.<p>One of GAE's biggest downsides is lack of control: unlike EC2 where you get to mold vanilla Linux installations to suit your needs, your application must fit GAE's service model through and through. But by giving up some of those freedoms you receive a whole lot of awesome in return. Khan Academy has successfully leveraged App Engine to scale to millions of users without hiring a single sysadmin or spending too much time worrying about anything ops-related. We're able to handle traffic spikes like our 60 Minutes appearance and the launch of our new computer science curriculum (<a href="http://khanacademy.org/cs" rel="nofollow">http://khanacademy.org/cs</a>) with no sweat. To deploy the site, any developer (or our friendly CI bot) can simply run our "deploy.py" and wait a few minutes, then get back to spending time on the product. We haven't had to think once about whether or not the database can handle the write load we throw at it; the App Engine Datastore is uniquely worry-free in that regard. (Well, I'm sure Google SREs worry about it plenty, but we don't have to.)<p>The GAE platform is a moving target, which is a Very Good Thing because it demonstrates Google's investment in the product and indicates that the App Engine team truly understands developer pain points and is working to solve them. I'll point to backends and Guido van Rossum's work on the NDB datastore interface as features that give GAE developers a little more freedom to use the platform in the most efficient way possible. If you're going to complain about lock-in, you might as well go all the way and take advantage of everything you get in return. You might find that it's not worth your time to replicate all of that elsewhere, especially when doing so on top of an IaaS provider like AWS introduces its own set of inefficiencies and points of failure.<p>P.S.: If you'd like to come work with great people on great stuff without worrying about keeping the site up, we're hiring: <a href="http://khanacademy.org/careers" rel="nofollow">http://khanacademy.org/careers</a>