<i>Technology Review: What's the problem you have most wanted to solve and haven't been able to?<p>Whitesides: There's an intellectual problem, which is the origin of life. The origin of life has the characteristic that there's something in there as a chemist, which I just don't understand. I don't understand how you go from a system that's random chemicals to something that becomes, in a sense, a Darwinian set of reactions that are getting more complicated spontaneously. I just don't understand how that works. So that's a scientific problem.</i><p>--This is a rare, intellectually honest view of Evolution. Notice, there is reasonable doubt. However so constrained.