> <i>Meanwhile, a digital agency designing a micro site for a client with [existing] assets and branding probably isn’t going to [benefit from Bootstrap].</i><p>I'm curious: why not? One of the major struggles I've seen at big companies and startups alike is the "6 different shades of red" issue that LESS helps with. Another common issue is every page being designed with a different layout because each section is created in a silo -- Bootstrap helps there with the grid and standard-issue components.<p>In the end, I suppose this isn't all exclusive to Bootstrap (you can make your own style guides and use your own grid). But it seems to me that Bootstrap - or any CSS framework, really - gives you some common ground on which to communicate with your designers.