I quite liked the look of RubyMotion <a href="http://www.rubymotion.com/developer-center/" rel="nofollow">http://www.rubymotion.com/developer-center/</a> for iOs development (as I fancied using Ruby) but I cant say I have tried it - sorry.
I was really hopeful of kivy [<a href="http://kivy.org/" rel="nofollow">http://kivy.org/</a>], but after playing around with it a little bit, it seemed very foreign to me, even though I program in Python daily. It seems very un-Pythonic, for lack of a better term.<p>On top of that, it seems to focus more on 3D than 2D, which is probably why there's so much there I'm less familiar with, but I mostly just want a decent 2D interface in Python.<p>I've had the best luck out of things like AppCelerator and Phonegap, but I've never been thrilled with the performance of either.