I am depressed due to social isolation, which others have mentioned, and constant career struggles. Past attempts to strike out on my own have failed, or just not succeeded enough. Software jobs pay extremely well, but at a cost of having to do someone else's crap work, including having to follow development practices that I'd never endorse myself.<p>As for the isolation, I'm introverted, mostly involved with a lot of reading, learning, and thinking. I get outside to exercise, but don't have much to talk to others about. I have no interest in the things that occupy the biggest part of shared reality, like sports, popular TV shows, or politics. I've had many girlfriends in the past, but could only get them and keep them by playing up a fake personality that was funny, tough, daring, sociable. It's been my experience that women respond best to a combination of theatrics and measured acquiescence, and that they will give you a lot of feedback on how they want you to be. But as soon as I "be myself" - they're bored or annoyed and then they're gone.<p>So, now I spend almost all my time by myself, and that's depressing. I wished I belonged to something. Also, I'm 35 and my life is almost identical to what it was a decade ago, except that my body is older and hurts more, so I always wonder why I don't feel a sense of progress.