This is how I use pngquant in my thumbnailing workflow: <a href="https://gist.github.com/gigablah/3110899" rel="nofollow">https://gist.github.com/gigablah/3110899</a><p>At 100x100 pixels, I find that this produces small (~8kb) PNG thumbnails which are still sharp with no noticeable color loss.<p>(Disclaimer: I'm a beginner at nodejs)