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Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

334 点作者 playhard超过 11 年前

23 条评论

pg超过 11 年前
Lest anyone be confused by that headline, there are 6 other nonprofits in the current batch. So there is a 7-way tie for 2nd nonprofit.
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mef超过 11 年前
Does anyone know why this approach is "viewed as a rogue project by the immunology community"? Is it just because it's new, or is there something more fundamental that conflicts with established immunology?
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icinnamon超过 11 年前
Hey everyone! Ian Cinnamon here from the Immunity Project YC team. The crowdfunding link in the article appears broken (we&#x27;re working on getting them to fix it). In the meantime, you can visit our campaign here: <a href="https://pledge.immunityproject.org/" rel="nofollow">https:&#x2F;&#x2F;pledge.immunityproject.org&#x2F;</a>
crystaln超过 11 年前
I&#x27;m trying to understand what if any overlap a pharmaceutical nonprofit has with any value YC could add, from the scale of funds required, to product advice, to business model - everything seems entirely out of the range of YC&#x27;s expertise.
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anu_gupta超过 11 年前
I&#x27;d like to understand why organisations like the Gates Foundation &#x2F; NIH aren&#x27;t excited by this approach? I&#x27;m assuming they&#x27;ve rejected this, which would explain the need to crowdfinance the next part. If they haven&#x27;t rejected it, why aren&#x27;t they being approached for grants?<p>Also, where&#x27;s the science? Having something in the FAQ that states &quot;We&#x27;re awaiting publication in a peer-reviewed journal&quot; is, to be blunt, pretty lame. Is the data and research open access? If not, why not?
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ig1超过 11 年前
Given the high cost (hundreds of millions) of taking a vaccine through clinical trials, FDA approval and production I&#x27;m curious why the choice to go the non-profit route.<p>Is the growth plan to raise the money from large donors (Gates foundation, Wellcome Trust, etc.) or to licence the technology to more traditional pharma firms ?
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andrewfong超过 11 年前
From the FAQ: &quot;But, there are certain spots on HIV that rarely mutate, and these are the same highly specific targets that controller immune systems already recognize naturally. Our vaccine trains your immune system to attack those weak spots so that the virus is crippled even when it mutates. In other words, our vaccine shows the prime targets to your immune system so that it does not have to waste time and energy trying to figure out which ones are the best points of attack.&quot;<p>How does the vaccine train your immune system? My (very limited) understanding of vaccines is that you would normally train the immune system to target these weak spots by creating an antibody that would bind to said weak spot. But from elsewhere on the page, it says that the project isn&#x27;t working on an antibody approach. What am I missing?
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unclebucknasty超过 11 年前
On one hand, it&#x27;s clearly great news that this work is being funded.<p>But, maybe I&#x27;m the odd guy, here. At a higher level, does it bother anyone else even slightly that more and more of the world&#x27;s priorities are being set by fewer and fewer people? This is how it&#x27;s been to some extent for millennia. But, with increasing income&#x2F;wealth disparity in the world, its effect is amplified.<p>This, of course, is a terrible example because I&#x27;m sure most can agree that attempting to cure such a devastating disease is worthy of funding. This is also not to disparage wealthy individuals (indeed, many would include me in the bunch).<p>It just seems that very little sees the light of day unless an increasingly small group of people deem it so worthy. And, something about seeing the priorities of even our non-profits dictated by these few gives me pause. Yes, I know that philanthropy, foundations, etc. have always existed but, again, the rate of increase of absolute power and control accreting back to so few people like the days of yore seems inconsistent with freedom, democracy, and all the other good stuff so many have come to idealize for good reason.
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rdl超过 11 年前
This is going to be really inconvenient for all the people who say &quot;sure, you are good at making photo sharing apps and dating sites, but you don&#x27;t cure cancer or anything.&quot;
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RoboTeddy超过 11 年前
How heavily does the project depend on obtaining correct target epitopes from Heckerman&#x27;s protein Gibbs free energy simulation?<p>Is there a chance that HIV won&#x27;t be controlled even if we can induce the immune system to be capable of targeting some of the peptide sequences that controllers often target? (i.e., might there be something else at work in controllers?)<p>Thanks for working on an important project!
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danielpal超过 11 年前
This is a really interesting project. I have so many questions and it seems others too. It would be great to do an AMA on Reddit or something.<p>So one question: This &quot;targetting capability&quot; that HIV controllers have, which your goals is to give it to all of us, does it also have any other benefits? Does it also help protect us from other viruses?
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jjoe超过 11 年前
This is one of those times when you take a step back, reflect, and look at the big picture. However much excited I am about my project, I realize that the stuff these guys are working on hits all the right notes. And then some.
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yarou超过 11 年前
Very interesting. I noticed the article mentions that the algorithm used is &quot;similar to the techniques of spam filtering&quot; (paraphrasing). Would it happen to be a Bayesian Network or a logical agent?
humanfromearth超过 11 年前
So have they developed a vaccine, but they need money for trials, delivery..? How exactly would they go about and test if it works on humans? Are there people who volunteer to get infected with HIV?
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FooBarWidget超过 11 年前
I don&#x27;t get it, isn&#x27;t the point of investing to get the investment back in many multiples? How do you get your investment back if it&#x27;s a non-profit?
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kfk超过 11 年前
Does this mean that contracting the virus with the vaccine will give you HIV but not AIDS? What about being a carrier, would you still be a carrier?
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cpursley超过 11 年前
I&#x27;m all for this; more power to them. However, HIV&#x2F;AIDS is already very preventable and had been on the decline for a decade or more. I&#x27;d rather see something like this effort, but for cancer. A disease that affects many more people.<p>Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don&#x27;t seem to have issues reproducing. Extending the human population, especially those of developing countries, only leads to more of the above. One day our children are going to say - &quot;Cool, no more HIV, but what&#x27;s a rainforest? what&#x27;s a Rhinoceros? why can&#x27;t we eat fish.&quot; Just saying.
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alt_f4超过 11 年前
Finally an answer to the question: &quot;What do I have to do to get into YCombinator? Cure aids?&quot;
kriro超过 11 年前
This is very good news. Good luck.
coreymgilmore超过 11 年前
great job guys, keep up the good work. cant wait to see what comes of it.
jonhmchan超过 11 年前
Just donated. Very cool.
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humannature超过 11 年前
when are we going to start addressing the problem of overpopulation?
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normloman超过 11 年前
That&#x27;ll never work. It has to involve social media somehow. Or apps.