Everything but the most well thought-out app is itself a SPOF.<p>1. design and develop solutions appropriate for your audience; consider their location, access to the network, and possible speed or lack thereof.<p>2. I love using professionally managed SLA-backed CDN's - like Akamai. A browser can only load so many items from the same host at one time, so I've found using a CDN helps, given my usage scenario. (see above)