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Patents that kill

61 点作者 graeham将近 11 年前

8 条评论

michaelq将近 11 年前
The simplest solution would be to significantly shorten the patent duration for pharmaceuticals, and start it the day a drug gets FDA approval. This would uncouple two things that should have never been coupled in the first place: development time and window of exclusivity in the market.
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dalek2point3将近 11 年前
here is the original paper in case anyone&#x27;s interested: <a href="http://www.nber.org/papers/w19430" rel="nofollow">http:&#x2F;&#x2F;www.nber.org&#x2F;papers&#x2F;w19430</a><p>And here is the abstract: Patents award innovators a fixed period of market exclusivity, e.g., 20 years in the United States. Yet, since in many industries firms file patents at the time of discovery (“invention”) rather than first sale (“commercialization”), effective patent terms vary: inventions that commercialize at the time of invention receive a full patent term, whereas inventions that have a long time lag between invention and commercialization receive substantially reduced - or in extreme cases, zero - effective patent terms. We present a simple model formalizing how this variation may distort research and development (R&amp;D). We then explore this distortion empirically in the context of cancer R&amp;D, where clinical trials are shorter - and hence, effective patent terms longer - for drugs targeting late-stage cancer patients, relative to drugs targeting early-stage cancer patients or cancer prevention. Using a newly constructed data set on cancer clinical trial investments, we provide several sources of evidence consistent with fixed patent terms distorting cancer R&amp;D. Back-of-the-envelope calculations suggest that the number of life-years at stake is large. We discuss three specific policy levers that could eliminate this distortion - patent design, targeted R&amp;D subsidies, and surrogate (non-mortality) clinical trial endpoints - and provide empirical evidence that surrogate endpoints can be effective in practice.
dnautics将近 11 年前
It keeps annoying me that nearly everyone (including Richard Posner [0] and notch [1]) says that &#x27;medicine makes for the best case for patents&#x27;. I&#x27;m not convinced that patents are necessary for pharmaceuticals, and I&#x27;m trying to prove that&#x27;s the case [2].<p>[0] <a href="http://www.theatlantic.com/business/archive/2012/07/why-there-are-too-many-patents-in-america/259725/" rel="nofollow">http:&#x2F;&#x2F;www.theatlantic.com&#x2F;business&#x2F;archive&#x2F;2012&#x2F;07&#x2F;why-ther...</a><p>[1] <a href="http://notch.tumblr.com/post/27751395263/on-patents" rel="nofollow">http:&#x2F;&#x2F;notch.tumblr.com&#x2F;post&#x2F;27751395263&#x2F;on-patents</a><p>[2] <a href="http://indysci.org/projectmarilyn" rel="nofollow">http:&#x2F;&#x2F;indysci.org&#x2F;projectmarilyn</a>
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tbrownaw将近 11 年前
Why is (well, <i>should</i>. Literal &quot;is&quot; is reasonably clear) drug exclusivity handled separately from drug approval? Since the one is needed to make up for the costs imposed by the other, shouldn&#x27;t they be handled as a unit under the same agency?
richardwigley将近 11 年前
&quot;A clinical trial for patients with metastatic prostate cancer lasts only three years compared to an 18-year-long trial for those suffering from a milder, localised prostate cancer. Since a typical patent is in force for 20 years, firms only have two years of effective patent length left to commercialise a new drug against localised prostate cancer.<p>The data paint a bleak picture. The economists find that pharmaceutical companies conduct 30 times more clinical trials for recurrent cancer drugs than for preventive drugs&quot;
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danielweber将近 11 年前
This is arguing for <i>longer</i> patents for drugs, since the 20-year-long patent causes the industry to only look for drugs where you can get through development and trials quickly enough that they enough years left on the patent to make revenue.
technotony将近 11 年前
The solution to this is regulatory exclusivity. The big cost is going through the FDA process, companies could simply be granted a 15 year exclusivity once they&#x27;ve passed that bar. The FDA already has a process setup for granting this.
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arikrak将近 11 年前
In general, regular capitalism is best for progress, since government-funded operations don&#x27;t have the same incentive to succeed, to avoid waste, etc.<p>However, for something like developing drugs, it may be worthwhile to have more government involvement. The article mentions how drug companies can focus on their profits to the detriment of society. One might even wonder if the Hepatitis C cure was priced so that not everyone could afford it, so the disease wouldn&#x27;t be eliminated...
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