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First Images of a Heart Injected with Liquid Metal

82 点作者 mwc将近 11 年前

9 条评论

gjmulhol将近 11 年前
I&#x27;ve worked a lot with liquid gallium (in semiconductors, not medicine) and it is pretty nasty stuff. It might not be very reactive, but it is extremely corrosive to other metals and can crystallize very quickly if given a seed.<p>A quick search for a gallium MSDS confirms that it isn&#x27;t exactly regarded as medically safe right now: <a href="https://www.rotometals.com/v/vspfiles/downloadables/MSDS_GALLIUM.pdf" rel="nofollow">https:&#x2F;&#x2F;www.rotometals.com&#x2F;v&#x2F;vspfiles&#x2F;downloadables&#x2F;MSDS_GAL...</a>
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graeham将近 11 年前
Bioengineering researcher here, who works mostly on analysis of vascular imaging.<p>Imaging in general is a field in medicine of increasingly growing importance - and as the article suggests its increasingly limited by resolution of the images. I personally see patient-specific diagnostics from image processing to be one of the most promising medical advances to expect in the coming decades. Image resolution is a major thing holding this back, it probably needs to improve ~2-5X for many applications.<p>This kind of thing is exciting, but probably at least a decade from clinical use, if at all from this particular technique. Use in research is itself quite interesting in at, at least to my knowledge, microvessels can only be observed by micro-dissection, which disturbs the tissue.<p>Being able to better observe microvessels clinically could have pretty big implications for heart attacks, strokes, cancers, and kidney functions.<p>The experiment (from the paper) was done on a in vitro (removed) pig heart (and kidneys, reported in the paper but not Medium article). In vitro studies often give much better images than in vivo because there is less<p>I am sceptical of the ability to retrieve the injected gallium, although I am not terribly familiar with its properties. I believe it is a quite rare and expensive metal, and the volumes needed for this would be small but not insignificant (maybe 20mL&#x2F; organ imaged?). I could see retrieving it being an issue, and particularly in the heart or brain, blood flow would need to be restored within a few minutes.<p>Iodine contrast agent, which this technique is compared against, is pretty nasty stuff. It gets filtered out by the kidneys, and is toxic to them. If anything, there is a movement to get away from contrast-based CT imaging of vessels and towards MRI or ultrasound, where contrast isn&#x27;t required.
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elwell将近 11 年前
On a related note, look at what gallium does to aluminium: <a href="http://youtu.be/9DEjE8jiwT8?t=1m7s" rel="nofollow">http:&#x2F;&#x2F;youtu.be&#x2F;9DEjE8jiwT8?t=1m7s</a>
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burke将近 11 年前
Somewhat higher resolution image on page 8 of <a href="http://arxiv.org/pdf/1311.6717v1.pdf" rel="nofollow">http:&#x2F;&#x2F;arxiv.org&#x2F;pdf&#x2F;1311.6717v1.pdf</a>
mrfusion将近 11 年前
Speaking of filling organs with metal, I&#x27;ve read that the lungs have an absolutely amazing amount of surface area. So I got to wondering if we could somehow use a lung (say removed from a pig) as a super capacitor?<p>Maybe use a non conductive material to thinly coat the inside of the lung and then fill it with metal?
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Cthulhu_将近 11 年前
I&#x27;d be very reluctant to have gallium injected in me, but it&#x27;s still a valuable technique to map out (and make casts of) hearts and vascular systems in animals or people that donate their body to science.
madaxe_again将近 11 年前
Neat, but unless this is in vivo, this isn&#x27;t all that thrilling, as we&#x27;ve been doing this sort of thing with wax and plastic for more than a century. <a href="http://cruciblezine.files.wordpress.com/2010/06/circulatory-network-0101.jpg" rel="nofollow">http:&#x2F;&#x2F;cruciblezine.files.wordpress.com&#x2F;2010&#x2F;06&#x2F;circulatory-...</a>
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MichaelApproved将近 11 年前
<i>And they say a small amount of the metal can be injected into the target vessels and sucked out afterwards without leaving a residue.&quot;</i><p>The most curious part of the story isn&#x27;t there, how do you suck out the metal afterwards? What percentage are you able to reliably <i>suck out</i>?
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disputin将近 11 年前
Needing some education here. They took a pig&#x27;s heart, dead, injected it with metal, and are impressed that this showed up in an x-ray? Gunther von Hagen with metal?