Amazon's new MySQL "cloud" MySQL service looks very positive on the surface, but there are a number of things that will need to be addressed before serious production use for large sites can leverage this offerings. They are:<p>1) Replication. Very very few large production Web sites run with one database server. The need to dynamically scale replicas and slave servers is critical for many Web applications.<p>2) Lock in to InnoDB tables. From what I've seen you can only run InnoDB tables. For some, MyISAM is a requirement, and in some cases provides better query performance.<p>These two issues right here are why I continue to run my MySQL server infrastructure myself in EC2. If and when they address those two critical components I'll most certainly give the new offering a hard look.