Over a decade ago, i worked in a lab that was trying to develop a gene therapy for DEB. It's particularly tough, because you need to replace the collagen VII gene, which is pretty big:<p><a href="http://www.omim.org/entry/120120" rel="nofollow">http://www.omim.org/entry/120120</a><p>That lab doesn't seem to have published anything since i left, but the broader project is still slowly grinding forward:<p><a href="http://www.genegraft.eu/" rel="nofollow">http://www.genegraft.eu/</a>