The general advice is - "Don't force it! It won't get you anywhere." However, I feel, smart ambitious people, can't avoid the anxiety to do their own thing. Leaving a high-paying job on a vital position might not make a lot of sense but I believe, when you are surrounded by people making multi-million dollar enterprises with almost-similar skill-set (maybe, with a better business sense), you can't avoid that feel of not finding a single reason to not to replicate the same level of success.