TE
科技回声
首页24小时热榜最新最佳问答展示工作
GitHubTwitter
首页

科技回声

基于 Next.js 构建的科技新闻平台,提供全球科技新闻和讨论内容。

GitHubTwitter

首页

首页最新最佳问答展示工作

资源链接

HackerNews API原版 HackerNewsNext.js

© 2025 科技回声. 版权所有。

Diet that mimics fasting appears to slow aging

301 点作者 jhartmann将近 10 年前

36 条评论

hathawsh将近 10 年前
The authors disclosed they have equity in a company called L-Nutra, which intends to sell diet food packs:<p><a href="http:&#x2F;&#x2F;www.l-nutra.com&#x2F;index.php&#x2F;products&#x2F;prolon" rel="nofollow">http:&#x2F;&#x2F;www.l-nutra.com&#x2F;index.php&#x2F;products&#x2F;prolon</a><p>Nothing for sale yet, but hopefully the price will be competitive with do-it-yourselfers. I am cautiously optimistic about this direction.
评论 #9743015 未加载
评论 #9741442 未加载
评论 #9741871 未加载
评论 #9742855 未加载
评论 #9742025 未加载
评论 #9745679 未加载
评论 #9742673 未加载
评论 #9742061 未加载
Rainymood将近 10 年前
I currently intermittent fast by skipping breakfast + lunch, partially because I&#x27;m lazy, partially because it allows me to easily eat &#x27;all my calories&#x27; in the end of the day. I really like this as it provides a &#x27;buffer&#x27; for unexpected food, such as random cake, or random lunches with colleagues etc.<p>Has anyone here actually ever TRIED fasting a full 24h day? I have. I HATED it. Well, the fasting itself wasn&#x27;t that bad, however, the next day my body went FULL berserk mode and I literally couldn&#x27;t stop myself from eating. It was really weird and I never had such strong biological urges. That&#x27;s when I decided I&#x27;d just stick to fasting until 5 pm when I eat diner.
评论 #9741912 未加载
评论 #9742242 未加载
评论 #9742318 未加载
评论 #9742139 未加载
评论 #9743005 未加载
评论 #9742056 未加载
评论 #9742128 未加载
评论 #9742158 未加载
评论 #9742548 未加载
评论 #9741669 未加载
评论 #9744209 未加载
评论 #9741781 未加载
评论 #9742957 未加载
评论 #9744705 未加载
评论 #9742969 未加载
评论 #9741659 未加载
评论 #9743524 未加载
评论 #9743613 未加载
评论 #9741663 未加载
评论 #9743038 未加载
评论 #9742116 未加载
评论 #9760208 未加载
评论 #9741675 未加载
reasonattlm将近 10 年前
There is much more background info on Longo and his work on intermittent fasting if you go digging. More interesting than this particular piece, which is very short on context and science relating to the study of intermittent fasting, calorie restriction as adjuvant cancer therapy, immune regeneration via fasting, etc.<p><a href="http:&#x2F;&#x2F;gero.usc.edu&#x2F;faculty&#x2F;longo&#x2F;" rel="nofollow">http:&#x2F;&#x2F;gero.usc.edu&#x2F;faculty&#x2F;longo&#x2F;</a><p><a href="http:&#x2F;&#x2F;www.eurekalert.org&#x2F;pub_releases&#x2F;2014-06&#x2F;uosc-fts060214.php" rel="nofollow">http:&#x2F;&#x2F;www.eurekalert.org&#x2F;pub_releases&#x2F;2014-06&#x2F;uosc-fts06021...</a><p><a href="http:&#x2F;&#x2F;michelsonmedical.org&#x2F;2014&#x2F;12&#x2F;26&#x2F;igf-1-fasting-discussion-valter-longo&#x2F;" rel="nofollow">http:&#x2F;&#x2F;michelsonmedical.org&#x2F;2014&#x2F;12&#x2F;26&#x2F;igf-1-fasting-discuss...</a><p><a href="http:&#x2F;&#x2F;news.usc.edu&#x2F;58074&#x2F;wanted-a-recipe-for-longevity&#x2F;" rel="nofollow">http:&#x2F;&#x2F;news.usc.edu&#x2F;58074&#x2F;wanted-a-recipe-for-longevity&#x2F;</a><p><a href="http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25498742" rel="nofollow">http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25498742</a><p><a href="http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25498743" rel="nofollow">http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25498743</a><p><a href="http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25549805" rel="nofollow">http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;news&#x2F;magazine-25549805</a>
评论 #9741837 未加载
评论 #9741631 未加载
评论 #9741549 未加载
评论 #9742230 未加载
krmmalik将近 10 年前
Appropriate article since I just completed a fast of 19hrs. No water and no food. Muslims do this every year. Last year, on average our fast was just over 18hrs. We fast each day from sunrise to sunset for 30days. Of course, we as a group of people have been doing it for over a thousand years. Cant say we started it due to science, but cant say we noticed the lack of aging either. ;)
评论 #9741744 未加载
评论 #9741770 未加载
评论 #9741896 未加载
评论 #9742447 未加载
jhartmann将近 10 年前
The paper in Cell Metabolism is here: <a href="http:&#x2F;&#x2F;www.cell.com&#x2F;cell-metabolism&#x2F;abstract&#x2F;S1550-4131(15)00224-7" rel="nofollow">http:&#x2F;&#x2F;www.cell.com&#x2F;cell-metabolism&#x2F;abstract&#x2F;S1550-4131(15)0...</a>
评论 #9741322 未加载
stevebmark将近 10 年前
Ketosis also &quot;mimics fastings&quot;, the main metabolic difference being nutritional ketosis is 0.5 - 3 mmol&#x2F;L, while fasting is 3 - 5 mmol&#x2F;L (betahydroxybuterate in the serum). The benefits of ketosis may also add longevity, possibly with similar mechanisms to fasting. It&#x27;s likely intermittent fasting put the subjects of the study into mild ketosis.<p>Bottom line: Ketosis may have benefits similar to fasting in terms of aging, but without having to fast :)
评论 #9741708 未加载
评论 #9741789 未加载
评论 #9741749 未加载
评论 #9741664 未加载
ohitsdom将近 10 年前
RadioLab did an interesting story on how fasting (or living through famines) impacts your children and grandchildren with significant health boosts.<p><a href="http:&#x2F;&#x2F;www.radiolab.org&#x2F;story&#x2F;251885-you-are-what-your-grandpa-eats&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.radiolab.org&#x2F;story&#x2F;251885-you-are-what-your-grand...</a>
toufique将近 10 年前
Appropriate article for the first day of Ramadan.
tkyjonathan将近 10 年前
There have been studies that prove that reducing meat consumption is the main benefit of fasting for slowing down ageing and that fasting has many negative psychological effects. If you eat foods with low amounts of the amino acids methionine and leucine, you could significantly reduce age-related diseases and the risk for certain cancers. <a href="http:&#x2F;&#x2F;nutritionfacts.org&#x2F;2015&#x2F;06&#x2F;11&#x2F;exploiting-autophagy-to-live-longer&#x2F;" rel="nofollow">http:&#x2F;&#x2F;nutritionfacts.org&#x2F;2015&#x2F;06&#x2F;11&#x2F;exploiting-autophagy-to...</a>
kazinator将近 10 年前
The connection between longevity and caloric intake has been studied in mice:<p><a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;3958810" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;3958810</a> [1986!]<p><i>&quot;Mice from groups 3-6 [restricted intake] exhibited mean and maximal life spans 35-65% greater than for group 1 and 20-40% greater than for group 2. Mice from group 6 [most restricted intake] lived longest of all.&quot;</i> Brackets mine.
评论 #9741446 未加载
评论 #9741383 未加载
评论 #9741613 未加载
revelation将近 10 年前
What was the research plan here? We want to investigate a diets impact on aging? What are the negative results then?<p>These are two extraordinarily complex, intertwined topics that to come up with a hypothesis like this on the limited evidence ends up appearing to be just a random search for correlations, terminating once you find one that has the right <i>p</i> value.
评论 #9741278 未加载
评论 #9741290 未加载
评论 #9741270 未加载
vannevar将近 10 年前
Before you take <i>any</i> diet science story seriously, read this: <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=9714985" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=9714985</a> . It&#x27;s sadly easy to generate &#x27;significant&#x27; results and get them published if you want to.
spectrum1234将近 10 年前
Stuff like this way more obvious if you start to think about it. Is putting your body in a safe bubble to live optimal? Does nurture always beat nature? Of course not. Some amount of stress and physical challenge MUST be optimal (defined as reduce aging). What USC just did here is pick a solid guess in the range of fairly optimal.<p>For the fasting parameter, (of many to choose from that cause stress or physical challenge) again with heuristics, we can first drill down to a sub-parameter of &quot;being fairly hungry&quot;. Given the previous logic, this variable must be a component of slowing aging.<p>Now if you had to guess from 1 day to 50 days or even 250 days, what would you guess is the optimal time of &quot;being fairly hungry&quot; to reduce aging? Mostly people would probably guess 2-10 days using the heuristics of &quot;one day is just too little to have an effect&quot; and &quot;15+ days just cant be safe for you body.&quot;<p>I&#x27;m surprised I hadn&#x27;t heard about a study like this before. What I am not surprised by is that the <i>optimal</i> range is right in the middle of the optimal range from simple heuristics.<p>The next heuristic you can tack on is timing between fasts. Using the same logic you will get very close to the timing between fasts USC is suggests.
rdl将近 10 年前
I&#x27;m curious if the health benefits of IF or moderate IF overwhelm the health detriment of appetite suppressant medications (e.g. amphetamines), in moderate doses.
dschiptsov将近 10 年前
Each and every Eastern religion emphasised fasting - Hindu and Muslims and Buddhists know the benefits of it.<p>Basically it means less burden, less load to the system (we are a system) and, as a by-product, the exercise of self-control, which is the key to personal success (delayed gratification and related concepts).<p>Thinking about tribal eating habits, one could realize that there is no single &quot;right&quot; diet, but a pepper set of habits of moderate austerity in consumption and sticking to simple, unprocessed, traditional (evolved according with local food sources) dishes.<p>To put it simply - conditioned by media overconsumption of processed junk food is the cause of suffering and a major contribution to ageing.
voidlogic将近 10 年前
Previously it has been found that eating a ketogenic diet (&lt;20g carbs&#x2F;day for most, adq. protien, most cals from fat) mimics long term caloric restriction- And, at least to me, that sounds much more appealing that eating a severe calorie deficient...<p>I lost 40 lbs on keto eating mostly (by volume) non-carby veggies and mostly (by calories) fat, along with 80-120g of protein per day. I&#x27;d really like to see their complex diet tested against a well formulated ketogenic diet.
评论 #9742925 未加载
评论 #9741804 未加载
brador将近 10 年前
What was the diet?
评论 #9741430 未加载
tosseraccount将近 10 年前
Haven&#x27;t they known this for a long time?<p><a href="http:&#x2F;&#x2F;jn.nutrition.org&#x2F;content&#x2F;31&#x2F;3&#x2F;363.full.pdf" rel="nofollow">http:&#x2F;&#x2F;jn.nutrition.org&#x2F;content&#x2F;31&#x2F;3&#x2F;363.full.pdf</a><p>APPARENT PROLONGATION OF THE LIFE SPAN OF RATS BY INTERMITTENT FASTING<p>by ANTON J. CARLSON AND FREDERICK HOELZEL Department of Physiology, University of Chicago, Chkago (Received for publication October 4, 1945 )
评论 #9741331 未加载
评论 #9741340 未加载
评论 #9741355 未加载
rmoyer将近 10 年前
This study is definitely leading up to an FDA (they hope) approved, marketable diet. The actual study does give some hints at what the diet is comprised of, &quot;to last 5 days every month and to provide between 34% and 54% of the normal caloric intake with a composition of at least 9%–10% proteins, 34%–47% carbohydrates, and 44%–56% fat&quot;. ... but reading further one finds this section: &quot;Human Diet The human fasting mimicking diet (FMD) program is a plant-based diet program designed to attain fasting-like effects while providing micronutrient nourishment (vitamins, minerals, etc.) and minimize the burden of fasting. It comprises proprietary vegetable-based soups, energy bars, energy drinks, chip snacks, chamomile flower tea, and a vegetable supplement formula tablet (Table S4). The human FMD diet consists of a 5 day regimen: day 1 of the diet supplies 1,090 kcal (10% protein, 56% fat, 34% carbohydrate), days 2–5 are identical in formulation and provide 725 kcal (9% protein, 44% fat, 4
评论 #9744685 未加载
tim333将近 10 年前
I was annoyed the article didn&#x27;t actually say what the diet was. Anyway from the Telegraph report of the same story:<p>Day one of the diet comprises:<p>10 per cent protein, 56 per cent fat and 34 per cent carbohydrate, making 1,090 calories<p>Days two to five:<p>Nine per cent protein, 44 per cent fat and 47 per cent carbohydrate making 725 calories
ajarmst将近 10 年前
Sigh. The plural of anecdote is not data, rodent studies are useful but only relevant for designing proper human studies (not replacing them), and any aging &quot;study&quot; that works with a few dozen subjects over a few months is not science but marketing.
subpixel将近 10 年前
If you&#x27;re interested, I highly recommend giving this a watch: <a href="http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;iplayer&#x2F;episode&#x2F;b01lxyzc&#x2F;horizon-20122013-3-eat-fast-and-live-longer" rel="nofollow">http:&#x2F;&#x2F;www.bbc.co.uk&#x2F;iplayer&#x2F;episode&#x2F;b01lxyzc&#x2F;horizon-201220...</a><p>(If you&#x27;re not in the UK, connecting via VPN works).<p>Twice a week fasting, where I eat a bowl of cereal and a piece of fruit and nothing else but coffee all day, has been working really well for me. Surprisingly, I&#x27;ve found I&#x27;m totally able to run a few miles on my fasting days to boot.
ams6110将近 10 年前
Anecdotally, when I was a kid I had goldfish at one point. I noticed that if they were fed daily they didn&#x27;t live very long. If they were fed once or twice a week they seemed to live forever.
评论 #9741920 未加载
评论 #9742686 未加载
评论 #9741728 未加载
codexjourneys将近 10 年前
I&#x27;ve seen this claim several times in connection with different studies. I believe the hugest benefits apply to organisms that eat a restricted number of calories for all or most of their lifespan.<p>And it&#x27;s probably not only the number of calories, but also the quality of food that matters. Nutrient-dense, low-calorie diets could be worth a try, but how long could you stick with them?<p>Giant page of research: <a href="http:&#x2F;&#x2F;qualitycounts.com&#x2F;fpcalorie.html" rel="nofollow">http:&#x2F;&#x2F;qualitycounts.com&#x2F;fpcalorie.html</a>
snthpy将近 10 年前
A lot of the pathways that are mentioned here in the comments were discussed at the &quot;Interventions to Slow Aging in Humans: Are We Ready?&quot; conference in Italy in 2013 that Valter Longo from the article was also part of. They reviewed the different pathways and summarised them here:<p><a href="http:&#x2F;&#x2F;onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1111&#x2F;acel.12338&#x2F;full" rel="nofollow">http:&#x2F;&#x2F;onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1111&#x2F;acel.12338&#x2F;full</a>
Mitchhhs将近 10 年前
This has been known for a long time. The big question is whether this can actually work in humans. Rhesus Monkey&#x27;s have shown some promising results, but the evidence is conflicting. I also wrote an article recently on this and other forms of lifespan extension: <a href="http:&#x2F;&#x2F;mitchkirby.com&#x2F;2015&#x2F;06&#x2F;02&#x2F;can-we-live-forever&#x2F;" rel="nofollow">http:&#x2F;&#x2F;mitchkirby.com&#x2F;2015&#x2F;06&#x2F;02&#x2F;can-we-live-forever&#x2F;</a>
usaphp将近 10 年前
I don&#x27;t know every time I skip a meal for 8+ hours since waking up in the morning I get a terrible headache and become mad at everybody around me, not sure if it&#x27;s just me or everybody who fastens have those symptoms. But when I eat breakfast and lunch I can go on without food till 4-5 am with no issues at all
评论 #9741922 未加载
评论 #9741826 未加载
guard-of-terra将近 10 年前
Can we have this in a pill? Science telling me to go fasting is same as if science told me to go walk instead of providing an automobile.<p>I know that it sounds unpositive but telling people how to live didn&#x27;t work for the last 2000 years, probably more. They fail at this always. But giving them tools help a lot.
dzhiurgis将近 10 年前
Any chance this could be related to this? <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Laron_syndrome#Clinical_characteristics" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Laron_syndrome#Clinical_charac...</a><p>I remember hearing about this in some BBC Horizon show.
erkkie将近 10 年前
The article in question <a href="http:&#x2F;&#x2F;www.cell.com&#x2F;cell-metabolism&#x2F;abstract&#x2F;S1550-4131(15)00224-7" rel="nofollow">http:&#x2F;&#x2F;www.cell.com&#x2F;cell-metabolism&#x2F;abstract&#x2F;S1550-4131(15)0...</a>
fasteo将近 10 年前
On the mechanistic side of things, it seems that fasting, among other things, cause a mild mitochondrial uncoupling[1]. This uncoupling seems the main reason for the extended life span[2]<p>If we give some credit to this hypothesis then yes, we will have a pill to slow down aging. It can go from a simple aspirin[3] (baby-aspirin anyone?), to the dangerous DNP in a low-dose, controlled release formulation[4], the novel cationic uncouplers [5], or the safe mitoBHT [6].<p>That said, you can just get a cold shower every morning[7]<p>I am even researching this area to treat my primary mitochondrial disfuntion[8]<p>[1] In simple terms, it means that the mitochondria generates less energy in the form of ATP and more energy as heat.<p>[2] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;21483800" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;21483800</a><p>[3] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC316328&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC316328&#x2F;</a><p>[4] <a href="http:&#x2F;&#x2F;onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1046&#x2F;j.1467-789X.2001.00043.x&#x2F;abstract" rel="nofollow">http:&#x2F;&#x2F;onlinelibrary.wiley.com&#x2F;doi&#x2F;10.1046&#x2F;j.1467-789X.2001....</a><p>[5] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;26071782" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;26071782</a><p>[6] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC2267406&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC2267406&#x2F;</a><p>[7] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;18335051" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;18335051</a><p>[8] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;21275885" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;21275885</a>
ziyadparekh将近 10 年前
What was the actual diet ?
评论 #9743542 未加载
eclipxe将近 10 年前
Another strong recommendation for Ketosis&#x2F;keto diet. Only thing that I&#x27;ve been able to lose weight with long term.
piyushpr134将近 10 年前
Hello from India, We know this since vedic times i.e. about 1750 to 500BC.<p>Thank you!
ommunist将近 10 年前
Just stick to porridge. And an apple a day keeps diet sellers away.
marvel_boy将近 10 年前
It worked (supposedly) in mice, not in humans. The title is misleading.
评论 #9741333 未加载
评论 #9741344 未加载